A prediction of hereditary effects in the offspring of irradiated parents remains one of the most important tasks and at the same time a fundamental issue for radiogenetics of generative cells for over 60 years. Nowadays, the relevance of this problem increases even more, in view of expanding human exposure to ionizing radiation on the Earth and in space, as well as the facing potential technical or military nuclear accidents.

The impossibility of studying this issue directly in humans makes extremely important the corresponding laboratory experiments in model organisms, whose gametogenesis is similar to that in humans (drosophila, mouse). The first steps in that direction were already made by classical genetics (1930s – 1950s) while investigating hereditary defects of separate genes in drosophilae and mice exposed to X-rays and gamma rays. The main results and weak points of those observations in comparison with the DLNP explorations were discussed. A molecular genetic research based on the DNA, DT and IT technologies marks a new milestone in science. Its first results were reported at the seminar.